2024
Reevaluating the Role of T2/FLAIR Mismatch Sign: Improving Diagnostic Accuracy With Qualitative MRI Features?
Willms K, von Reppert M, Lost J, Tillmanns N, Merkaj S, Huttner A, Schrickel E, Memon F, Aboian M. Reevaluating the Role of T2/FLAIR Mismatch Sign: Improving Diagnostic Accuracy With Qualitative MRI Features? Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2024 DOI: 10.58530/2024/3586.Peer-Reviewed Original ResearchT2/FLAIR mismatch signIDH-mutant gliomasT2/FLAIR-mismatchVASARI featuresDiagnostic accuracyAccurate preoperative diagnosisIDH-mutant astrocytomasAccurate patient managementQualitative MRI featuresImproving diagnostic accuracyPreoperative diagnosisIDH-mutantImproved diagnostic toolsMRI featuresEnhanced diagnostic methodMismatch signGlioma subtypesPatient managementGlioma cohortGliomaNoninvasive methodDiagnostic precisionDiagnostic methodsDiagnostic toolAstrocytoma
2019
In vivo 13C and 1H‐[13C] MRS studies of neuroenergetics and neurotransmitter cycling, applications to neurological and psychiatric disease and brain cancer
Rothman DL, de Graaf R, Hyder F, Mason GF, Behar KL, De Feyter HM. In vivo 13C and 1H‐[13C] MRS studies of neuroenergetics and neurotransmitter cycling, applications to neurological and psychiatric disease and brain cancer. NMR In Biomedicine 2019, 32: e4172. PMID: 31478594, DOI: 10.1002/nbm.4172.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2017
Transcranial MRI‐guided high‐intensity focused ultrasound for treatment of essential tremor: A pilot study on the correlation between lesion size, lesion location, thermal dose, and clinical outcome
Federau C, Goubran M, Rosenberg J, Henderson J, Halpern CH, Santini V, Wintermark M, Pauly K, Ghanouni P. Transcranial MRI‐guided high‐intensity focused ultrasound for treatment of essential tremor: A pilot study on the correlation between lesion size, lesion location, thermal dose, and clinical outcome. Journal Of Magnetic Resonance Imaging 2017, 48: 58-65. PMID: 29076274, DOI: 10.1002/jmri.25878.Peer-Reviewed Original ResearchConceptsMedication-refractory essential tremorClinical outcomesEssential tremorThalamic nucleiLesion volumeLesion sizeAnterior commissure-posterior commissure planeLateral posterior thalamic nucleusPilot studyFinal lesion volumePosterior thalamic nucleusPromising noninvasive methodWilcoxon twoVentral divisionPosttreatment imagesLesion locationYear posttreatmentPosterior commissureScore improvementDoseNoninvasive methodTremorJ. MagnStatistical significanceTechnical efficacy
2015
Early detection of pancreatic cancer.
Kim VM, Ahuja N. Early detection of pancreatic cancer. Chinese Journal Of Cancer Research 2015, 27: 321-31. PMID: 26361402, PMCID: PMC4560741, DOI: 10.3978/j.issn.1000-9604.2015.07.03.Peer-Reviewed Original ResearchPancreatic cancerPancreatic adenocarcinomaRisk factorsEarly detectionFourth common causeNew cancer casesGenetic risk factorsCancer deathCancer mortalityDefinitive curePrecursor lesionsCancer casesCommon causeWidespread screeningRisk-based strategyCancerNoninvasive methodGenetic mutationsMortal diseaseAdenocarcinomaCurrent standardDiseaseBest chanceClear needCauseAntifibrotic Therapies in the Liver
Mehal W, Schuppan D. Antifibrotic Therapies in the Liver. Seminars In Liver Disease 2015, 35: 184-198. PMID: 25974903, PMCID: PMC5743222, DOI: 10.1055/s-0035-1550055.Peer-Reviewed Original ResearchConceptsAntifibrotic therapyIdeal patient populationRegression of fibrosisBest noninvasive methodFibrolytic propertiesDose titrationClinical outcomesFibrosis regressionPulmonary fibrosisPatient populationCombination therapyLiver fibrosisIndividualized therapyEncouraging dataFibrotic responseTherapeutic targetDrug AdministrationFibrosisTherapyNoninvasive methodInterindividual heterogeneityCell populationsAntifibroticsLiverFibrolysis
2014
Test-retest variability of adenosine A2A binding in the human brain with 11C-TMSX and PET
Naganawa M, Mishina M, Sakata M, Oda K, Hiura M, Ishii K, Ishiwata K. Test-retest variability of adenosine A2A binding in the human brain with 11C-TMSX and PET. EJNMMI Research 2014, 4: 76. PMID: 25621197, PMCID: PMC4293456, DOI: 10.1186/s13550-014-0076-9.Peer-Reviewed Original ResearchTest-retest variabilityCerebral cortexCentrum semiovaleMethodsFive healthy volunteersNon-displaceable uptakeLow test-retest variabilityReference regionArterial blood samplingTest-retest reproducibilityCandidate reference regionsHuman brainTest-retest studyHealthy volunteersAdenosine A2ABlood samplingDistribution volumeInvasive methodNoninvasive methodReceptor quantificationBPNDCortexBrainPresent studySimilar levelsPETChapter 4.2 Carbon (13C) MRS
Rothman D, De Feyter H. Chapter 4.2 Carbon (13C) MRS. 2014, 312-330. DOI: 10.1016/b978-0-12-401688-0.00023-9.ChaptersNeurotransmitter cyclingHigh neuronal activityHuman brain diseasesOnly noninvasive methodBrain metabolismGlutamate neurotransmissionNeuronal activityMRS studiesPsychiatric diseasesNeuronal functionBrain diseasesBrain functionClinical researchNeuroenergeticsNoninvasive methodDiseaseMRSMRS measurementsHuman researchBrain statesRecent findingsImportant new informationHumansMetabolic pathwaysNeurotransmission
2013
Tracer Kinetic Modeling of [11C]AFM, a New PET Imaging Agent for the Serotonin Transporter
Naganawa M, Nabulsi N, Planeta B, Gallezot JD, Lin SF, Najafzadeh S, Williams W, Ropchan J, Labaree D, Neumeister A, Huang Y, Carson RE. Tracer Kinetic Modeling of [11C]AFM, a New PET Imaging Agent for the Serotonin Transporter. Cerebrovascular And Brain Metabolism Reviews 2013, 33: 1886-1896. PMID: 23921898, PMCID: PMC3851894, DOI: 10.1038/jcbfm.2013.134.Peer-Reviewed Original ResearchConceptsPositron emission tomographySerotonin transporterReference tissue modelArterial input functionOne-tissue modelMultilinear reference tissue modelNew PET imaging agentTwo-tissue modelPET imaging agentHealthy human brainSuitable PET radioligandNew positron emission tomographySERT densityRegional time-activity curvesTime-activity curvesEmission tomography dataRegional bindingEmission tomographyPET radioligandRoutine useInterest analysisNoninvasive methodPositron emission tomography dataImaging agentHuman brainCapnography in the pediatric emergency department: clinical applications
Becker HJ, Langhan M. Capnography in the pediatric emergency department: clinical applications. Pediatric Emergency Medicine Practice 2013, 10: 1-24. PMID: 31692301.Peer-Reviewed Original ResearchPediatric emergency departmentEmergency departmentEmergency cliniciansConfirmation of intubationUse of capnographyLower respiratory diseaseEnd-tidal carbon dioxide monitoringClinical applicationMaintenance of ventilationInterpretation of waveformsNonintubated childrenPediatric patientsMetabolic derangementsMonitoring of effectivenessSedated childrenCarbon dioxide monitoringCardiopulmonary resuscitationMetabolic parametersRespiratory diseasePediatric subspecialtiesPatient careCapnographyClinical useNoninvasive methodClinicians
2012
Usefulness of Noninvasive Fractional Flow Reserve Computed from Coronary Computed Tomographic Angiograms for Intermediate Stenoses Confirmed by Quantitative Coronary Angiography
Min JK, Koo BK, Erglis A, Doh JH, Daniels DV, Jegere S, Kim HS, Dunning AM, DeFrance T, Lansky A, Leipsic J. Usefulness of Noninvasive Fractional Flow Reserve Computed from Coronary Computed Tomographic Angiograms for Intermediate Stenoses Confirmed by Quantitative Coronary Angiography. The American Journal Of Cardiology 2012, 110: 971-976. PMID: 22749390, DOI: 10.1016/j.amjcard.2012.05.033.Peer-Reviewed Original ResearchConceptsLesion-specific ischemiaFractional flow reserveCoronary lesionsIntermediate stenosisFlow reservePredictive valueNoninvasive methodComputed Tomographic AngiogramsCoronary computed tomographyNoninvasive fractional flow reserveQuantitative coronary angiographyReceiver operator characteristic curveIntermediate stenosis severityNegative predictive valuePositive predictive valueOperator characteristic curveCoronary angiographyInvasive angiographyMean ageTomographic angiogramBland-Altman analysisStudy groupIschemiaComputed tomographyNovel noninvasive method
2011
13C MRS studies of neuroenergetics and neurotransmitter cycling in humans
Rothman DL, De Feyter HM, de Graaf R, Mason GF, Behar KL. 13C MRS studies of neuroenergetics and neurotransmitter cycling in humans. NMR In Biomedicine 2011, 24: 943-957. PMID: 21882281, PMCID: PMC3651027, DOI: 10.1002/nbm.1772.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsNeurotransmitter cyclingMRS studiesHigh neuronal activityHuman brain diseasesOnly noninvasive methodBrain metabolismGlutamate neurotransmissionNeuronal activityPsychiatric diseasesNeuronal functionBrain diseasesBrain functionClinical researchNeuroenergeticsNoninvasive methodMRSMRS measurementsHuman researchDiseaseBrain statesRecent findingsImportant new informationHumansMetabolic pathwaysNeurotransmissionLocalization of focal epileptic discharges using functional connectivity magnetic resonance imaging.
Stufflebeam S, Liu H, Sepulcre J, Tanaka N, Buckner R, Madsen J. Localization of focal epileptic discharges using functional connectivity magnetic resonance imaging. Journal Of Neurosurgery 2011, 114: 1693-7. PMID: 21351832, PMCID: PMC3248962, DOI: 10.3171/2011.1.jns10482.Peer-Reviewed Original ResearchConceptsEpileptic dischargesRefractory epilepsyMedically refractory epilepsyFocal epileptic dischargesLocalized epileptic dischargesSeizure onset zoneMagnetic resonance imagingFunctional connectivity magnetic resonance imagingStatistically significant increaseSurgical treatmentEpileptogenic areaSpontaneous brain activityInvasive electroencephalographyOnset zonePatientsResonance imagingMR imagingHigh-spatial resolutionNoninvasive methodSignificant increasePresurgical mappingFocal regionFCMREpilepsy
2009
Results of Exercise Stress Testing in Patients with Diffuse Pulmonary Arteriovenous Malformations
Murphy J, Pierucci P, Chyun D, Henderson KJ, Pollak J, White RI, Fahey J. Results of Exercise Stress Testing in Patients with Diffuse Pulmonary Arteriovenous Malformations. Pediatric Cardiology 2009, 30: 978-984. PMID: 19636485, DOI: 10.1007/s00246-009-9491-5.Peer-Reviewed Original ResearchConceptsDiffuse pulmonary arteriovenous malformationsExercise stress testingPulmonary arteriovenous malformationsOxygen saturationMaximum exerciseArteriovenous malformationsRoom air oxygen saturationMean oxygen saturationStress testingCycle ergometer testNoncontrast chestBilateral involvementFrequent complicationComplete embolizationSerial studiesPatientsErgometer testOwn controlYoung adultsNoninvasive methodLimited experienceSignificant differencesMalformationsBaselineAge
2007
Delayed-Enhancement Cardiovascular Magnetic Resonance Coronary Artery Wall Imaging Comparison With Multislice Computed Tomography and Quantitative Coronary Angiography
Yeon SB, Sabir A, Clouse M, Martinezclark PO, Peters DC, Hauser TH, Gibson CM, Nezafat R, Maintz D, Manning WJ, Botnar RM. Delayed-Enhancement Cardiovascular Magnetic Resonance Coronary Artery Wall Imaging Comparison With Multislice Computed Tomography and Quantitative Coronary Angiography. Journal Of The American College Of Cardiology 2007, 50: 441-447. PMID: 17662397, DOI: 10.1016/j.jacc.2007.03.052.Peer-Reviewed Original ResearchConceptsQuantitative coronary angiographyCoronary artery wallCoronary vessel wallCoronary angiographyRisk factorsArtery wallCardiovascular risk factorsCoronary artery diseaseCoronary artery stenosisSeverity of atherosclerosisCoronary vessel wall imagingVessel wallMultislice Computed TomographyVessel wall imagingArtery diseaseCoronary diseaseArtery stenosisNoncalcified plaqueCoronary segmentsDE-CMRHealthy subjectsComputed tomographyGreater prevalenceMSCTNoninvasive method
2001
Whole genome amplification increases the efficiency and validity of buccal cell genotyping in pediatric populations.
Zheng S, Ma X, Buffler PA, Smith MT, Wiencke JK. Whole genome amplification increases the efficiency and validity of buccal cell genotyping in pediatric populations. Cancer Epidemiology Biomarkers & Prevention 2001, 10: 697-700. PMID: 11401921.Peer-Reviewed Original ResearchConceptsPediatric populationBuccal cellsNurse-administered protocolGlutathione S-transferase muPediatric acute leukemiaMethylenetetrahydrofolate reductase (MTHFR) polymorphismsPeripheral whole bloodGlutathione S-transferase thetaAcute leukemiaCytology brushWhole genome amplificationChildhood leukemiaBone marrowBuccal cell DNANoninvasive methodWhole bloodRepeat testsSuccess rateGenome amplificationOngoing studiesBuccal samplesLeukemiaBloodBuccal DNACell DNA
1998
Lateralization of human temporal lobe epilepsy by 31P NMR spectroscopic imaging at 4.1 T
Chu W, Hetherington H, Kuzniecky R, Simor T, Mason G, Elgavish G. Lateralization of human temporal lobe epilepsy by 31P NMR spectroscopic imaging at 4.1 T. Neurology 1998, 51: 472-479. PMID: 9710021, DOI: 10.1212/wnl.51.2.472.Peer-Reviewed Original ResearchConceptsMesial temporal lobeTemporal lobe epilepsy patientsTemporal lobe epilepsyPCr/PiTemporal lobeClinical lateralizationLobe epilepsySeizure focusEpilepsy patientsHealthy volunteersHuman temporal lobe epilepsyPi ratioSubgroup of patientsIpsilateral lobePresurgical lateralizationContralateral lobeLateralization resultsPatientsMetabolite ratiosNoninvasive modalityNoninvasive methodLateralizationScalp EEGAnterior regionIntracranial EEG
1997
Functional MRI bold signal coincides with electrical activity in the rat whisker barrels
Yang X, Hyder F, Shulman R. Functional MRI bold signal coincides with electrical activity in the rat whisker barrels. Magnetic Resonance In Medicine 1997, 38: 874-877. PMID: 9402186, DOI: 10.1002/mrm.1910380604.Peer-Reviewed Original ResearchConceptsRat whisker barrelsElectrical activityFunctional MRIWhisker barrelsBlood oxygenation level-dependent (BOLD) image contrastBrain functional activityBOLD fMRI signalNeuronal electrical activitySustained stimulationFunctional activationNoninvasive methodFunctional activityFMRI signalsPerfusionRat whiskerLocalized increaseActivityMRI
1995
Functional magnetic resonance imaging of sensory and motor cortex: comparison with electrophysiological localization.
Puce A, Constable R, Luby M, McCarthy G, Nobre A, Spencer D, Gore J, Allison T. Functional magnetic resonance imaging of sensory and motor cortex: comparison with electrophysiological localization. Journal Of Neurosurgery 1995, 83: 262-70. PMID: 7616272, DOI: 10.3171/jns.1995.83.2.0262.Peer-Reviewed Original ResearchConceptsSensorimotor cortexFunctional magnetic resonance imagingMagnetic resonance imagingFunctional MR imagingMotor cortexElectrical stimulationResonance imagingMR imagingUseful noninvasive methodSensory tasksRefractory seizuresMedian nerveAxial gradient echo imagesNormal subjectsSensorimotor areasElectrophysiological localizationFunctional assessmentPrimary sensoryCentral sulcusThenar regionCortexMotor tasksNoninvasive methodGradient-echo imagesPatients
1989
Comparison of Cytobrush and cervicovaginal lavage sampling methods for the detection of genital human papillomavirus
Goldberg G, Vermund S, Schiffman M, Ritter D, Spitzer C, Burk R. Comparison of Cytobrush and cervicovaginal lavage sampling methods for the detection of genital human papillomavirus. American Journal Of Obstetrics And Gynecology 1989, 161: 1669-1672. PMID: 2557764, DOI: 10.1016/0002-9378(89)90947-2.Peer-Reviewed Original ResearchConceptsHuman papillomavirus deoxyribonucleic acidCervicovaginal lavageHuman papillomavirusGenital human papillomavirusFemale lower genital tractNoninvasive methodHuman papillomavirus infectionLower genital tractSensitive noninvasive methodExfoliated cervical cellsComparison of cytobrushSubstantial clinical importanceColposcopy clinicPapillomavirus infectionCervical neoplasiaGenital tractLavagePapillomavirusClinical importanceEtiologic agentCervical cellsPatientsDeoxyribonucleic acidSouthern blot hybridizationCellsTears of the triangular fibrocartilage of the wrist: MR imaging.
Golimbu C, Firooznia H, Melone C, Rafii M, Weinreb J, Leber C. Tears of the triangular fibrocartilage of the wrist: MR imaging. Radiology 1989, 173: 731-3. PMID: 2813778, DOI: 10.1148/radiology.173.3.2813778.Peer-Reviewed Original ResearchConceptsSurgical findingsMR imagingSoft-tissue swellingTriangular fibrocartilage tearsValuable noninvasive methodMagnetic resonance imagingUnderwent surgerySurgical correlationTFC tearsAccuracy of MRSpecific complaintsPatientsMedial sideTriangular fibrocartilagePathologic conditionsResonance imagingMR diagnosisBasis of findingsNoninvasive methodTearsDiagnosisWristSurgeryImagingFindings
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