2024
Rainfall events and daily mortality across 645 global locations: two stage time series analysis
He C, Breitner-Busch S, Huber V, Chen K, Zhang S, Gasparrini A, Bell M, Kan H, Royé D, Armstrong B, Schwartz J, Sera F, Vicedo-Cabrera A, Honda Y, Jaakkola J, Ryti N, Kyselý J, Guo Y, Tong S, de'Donato F, Michelozzi P, Coelho M, Saldiva P, Lavigne E, Orru H, Indermitte E, Pascal M, Goodman P, Zeka A, Kim Y, Diaz M, Arellano E, Overcenco A, Klompmaker J, Rao S, Palomares A, Carrasco G, Seposo X, Pereira da Silva S, Madureira J, Holobaca I, Scovronick N, Acquaotta F, Kim H, Lee W, Hashizume M, Tobias A, Íñiguez C, Forsberg B, Ragettli M, Guo Y, Pan S, Osorio S, Li S, Zanobetti A, Dang T, Van Dung D, Schneider A. Rainfall events and daily mortality across 645 global locations: two stage time series analysis. The BMJ 2024, 387: e080944. PMID: 39384295, DOI: 10.1136/bmj-2024-080944.Peer-Reviewed Original ResearchMeSH KeywordsCardiovascular DiseasesCause of DeathGlobal HealthHumansMortalityRainRespiratory Tract DiseasesTime FactorsConceptsYear return periodReturn periodsRainfall eventsVegetation coverageCharacteristics of daily rainfallDaily rainfall intensityDaily rainfallRainfall intensityRespiratory mortalityClimate typesRainfallLocal climateIntensity indexGlobal scaleTime series analysisMortality riskRelative riskAssociated with respiratory mortalityDaily mortalityDaily mortality dataClimateEstimate mortality riskIncreased relative riskSeries analysisGlobal locationsAll-cause, cardiovascular, and respiratory mortality and wildfire-related ozone: a multicountry two-stage time series analysis
Chen G, Guo Y, Yue X, Xu R, Yu W, Ye T, Tong S, Gasparrini A, Bell M, Armstrong B, Schwartz J, Jaakkola J, Lavigne E, Saldiva P, Kan H, Royé D, Urban A, Vicedo-Cabrera A, Tobias A, Forsberg B, Sera F, Lei Y, Abramson M, Li S, Network M, Abrutzky R, Alahmad B, Ameling C, Åström C, Breitner S, Carrasco-Escobar G, de Sousa Zanotti Stagliorio Coêlho M, Colistro V, Correa P, Dang T, de'Donato F, Van Dung, Entezari A, Garcia S, Garland R, Goodman P, Guo Y, Hashizume M, Holobaca I, Honda Y, Houthuijs D, Hurtado-Díaz M, Íñiguez C, Katsouyanni K, Kim H, Kyselý J, Lee W, Maasikmets M, Madureira J, Mayvaneh F, Nunes B, Orru H, Ortega N, Overcenco A, Pan S, Pascal M, Ragettli M, Rao S, Ryti N, Samoli E, Schneider A, Scovronick N, Seposo X, Stafoggia M, De la Cruz Valencia C, Zanobetti A, Zeka A. All-cause, cardiovascular, and respiratory mortality and wildfire-related ozone: a multicountry two-stage time series analysis. The Lancet Planetary Health 2024, 8: e452-e462. PMID: 38969473, DOI: 10.1016/s2542-5196(24)00117-7.Peer-Reviewed Original ResearchMeSH KeywordsAir PollutantsAir PollutionCardiovascular DiseasesEnvironmental ExposureGlobal HealthHumansOzoneRespiratory Tract DiseasesWildfiresConceptsRespiratory mortalityImpact of wildfiresDaily respiratory mortalityDaily cardiovascular mortalityTwo-stage time-series analysisChemical transport modelWildfire activityDaily mortality ratesDaily concentrationsDaily mortalityStudy locationRespiratory deathsWildfireManagement strategiesSource of tropospheric ozoneTransport modelTropospheric ozoneGlobal levelLocation levelMulti-cityRegional levelMortality fractionsEffective riskSouth AmericaCentral America
2023
Rehabilitation for People with Respiratory Disease and Frailty: An Official American Thoracic Society Workshop Report
Maddocks M, Brighton L, Alison J, Beek L, Bhatt S, Brummel N, Burtin C, Cesari M, Evans R, Ferrante L, Flores-Flores O, Franssen F, Garvey C, Harrison S, Iyer A, Lahouse L, Lareau S, Lee A, Man W, Marengoni A, McAuley H, Rozenberg D, Singer J, Spruit M, Osadnik C. Rehabilitation for People with Respiratory Disease and Frailty: An Official American Thoracic Society Workshop Report. Annals Of The American Thoracic Society 2023, 20: 767-780. PMID: 37261787, PMCID: PMC10257033, DOI: 10.1513/annalsats.202302-129st.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAgedFrailtyHumansPalliative CareRespiration DisordersRespiratory Tract DiseasesTelerehabilitationUnited StatesConceptsRespiratory diseasePulmonary rehabilitationOfficial American Thoracic Society Workshop ReportHome-based pulmonary rehabilitationAmerican Thoracic Society workshopPalliative care expertiseIdentification of frailtyChronic respiratory diseasesRole of rehabilitationWorse health outcomesOnward referralSymptom burdenExercise prescriptionSpecialist inputCare expertiseHealth outcomesFrailtyDiseaseAvailable evidenceRehabilitationOutcomesBasis of sensitivityWorkshop reportComprehensive assessmentComorbiditiesEffects of heat waves on cardiovascular and respiratory mortality in Rio de Janeiro, Brazil
Silveira I, Cortes T, Bell M, Junger W. Effects of heat waves on cardiovascular and respiratory mortality in Rio de Janeiro, Brazil. PLOS ONE 2023, 18: e0283899. PMID: 37000782, PMCID: PMC10065291, DOI: 10.1371/journal.pone.0283899.Peer-Reviewed Original ResearchMeSH KeywordsAgedBrazilCardiovascular DiseasesCross-Over StudiesFemaleHot TemperatureHumansMortalityRespiratory Tract DiseasesTemperatureConceptsRespiratory mortalityOdds ratioDistributed lag non-linear modelCardiovascular mortalityIndividual-level exposuresHeat wave intensityCase-crossover studyConditional logistic regressionMunicipal Health DepartmentHeat wavesEffects of heat wavesHealth impacts of heat wavesHealth departmentsHealth resourcesDeath dataOlder peopleLow-incomeEffect estimatesOlder womenDefinition of heat wavesLogistic regressionEpidemiological evidenceMorbidity outcomesHeat wave daysHealth impactsShort-term association between ambient air pollution and cardio-respiratory mortality in Rio de Janeiro, Brazil
Cortes T, Silveira I, de Oliveira B, Bell M, Junger W. Short-term association between ambient air pollution and cardio-respiratory mortality in Rio de Janeiro, Brazil. PLOS ONE 2023, 18: e0281499. PMID: 36795640, PMCID: PMC9934392, DOI: 10.1371/journal.pone.0281499.Peer-Reviewed Original ResearchMeSH KeywordsAir PollutantsAir PollutionBrazilCross-Over StudiesEnvironmental ExposureEnvironmental PollutantsHumansOzoneParticulate MatterRespiration DisordersRespiratory Tract DiseasesConceptsAmbient air pollutionCardio-respiratory mortalityShort-term associationsAir pollutionRespiratory mortalityExposure to particulate matter <Individual-level mortality dataOdds ratioIndividual exposure to air pollutionExposure to air pollutionCase-crossover study designHealth risk estimatesConditional logistic regression modelsConfidence intervalsEvaluation of public healthParticulate matter <Inverse distance weighting methodExposure assessment methodsIndividual-level dataDistributed lag non-linear modelLogistic regression modelsDistance weighting methodPM10 exposurePollution exposureRio de JaneiroHeat-related cardiorespiratory mortality: Effect modification by air pollution across 482 cities from 24 countries
Rai M, Stafoggia M, de'Donato F, Scortichini M, Zafeiratou S, Vazquez Fernandez L, Zhang S, Katsouyanni K, Samoli E, Rao S, Lavigne E, Guo Y, Kan H, Osorio S, Kyselý J, Urban A, Orru H, Maasikmets M, Jaakkola J, Ryti N, Pascal M, Hashizume M, Fook Sheng Ng C, Alahmad B, Hurtado Diaz M, De la Cruz Valencia C, Nunes B, Madureira J, Scovronick N, Garland R, Kim H, Lee W, Tobias A, Íñiguez C, Forsberg B, Åström C, Maria Vicedo-Cabrera A, Ragettli M, Leon Guo Y, Pan S, Li S, Gasparrini A, Sera F, Masselot P, Schwartz J, Zanobetti A, Bell M, Schneider A, Breitner S. Heat-related cardiorespiratory mortality: Effect modification by air pollution across 482 cities from 24 countries. Environment International 2023, 174: 107825. PMID: 36934570, DOI: 10.1016/j.envint.2023.107825.Peer-Reviewed Original ResearchMeSH KeywordsAir PollutantsAir PollutionCardiovascular DiseasesCitiesEnvironmental ExposureEnvironmental PollutantsHot TemperatureHumansMortalityParticulate MatterRespiratory Tract DiseasesConceptsAir pollutionRespiratory mortalityWHO air quality guidelinesElevated levels of air pollutionLevels of air pollutionAir quality guidelinesAmbient air pollutionLevel of pollutionCause-specific mortalityCardiovascular mortalityQuality guidelinesDaily death countsPollutant concentrationsCardiorespiratory mortalityPotential interactive effectsPollutionMitigation measuresPromote sustainable developmentMeta-analytic modelEffect modificationInteractive effects of heatSummer temperaturesSummer monthsExposure dataDeath counts
2022
Spatiotemporal varying coefficient model for respiratory disease mapping in Taiwan
Wang F, Duan C, Li Y, Huang H, Shia B. Spatiotemporal varying coefficient model for respiratory disease mapping in Taiwan. Biostatistics 2022, 25: 40-56. PMID: 36484310, DOI: 10.1093/biostatistics/kxac046.Peer-Reviewed Original ResearchMeSH KeywordsAir PollutantsAir PollutionBayes TheoremEnvironmental MonitoringHumansParticulate MatterRespiration DisordersRespiratory Tract DiseasesTaiwanConceptsHospital visit ratesFinite sample performanceVisit ratesBayesian disease mapping modelsGlobal public health problemIntegrated Nested Laplace ApproximationSpatially varying coefficientsPublic health problemNested Laplace ApproximationSample performanceRespiratory diseaseDisease mapping modelsAir pollutionLaplace approximationHealth problemsRespiratory disease dataTemporal trendsEffect of Early vs Standard Approach to Tracheostomy on Functional Outcome at 6 Months Among Patients With Severe Stroke Receiving Mechanical Ventilation
Bösel J, Niesen WD, Salih F, Morris NA, Ragland JT, Gough B, Schneider H, Neumann JO, Hwang DY, Kantamneni P, James ML, Freeman WD, Rajajee V, Rao CV, Nair D, Benner L, Meis J, Klose C, Kieser M, Suarez JI, Schönenberger S, Seder DB, Ramadan A, Claassen J, Mayer S, Peled H, Christianson T, May T, Riker R, Asgarpur G, Stetefeld H, Kluge S. Effect of Early vs Standard Approach to Tracheostomy on Functional Outcome at 6 Months Among Patients With Severe Stroke Receiving Mechanical Ventilation. JAMA 2022, 327: 1899-1909. PMID: 35506515, PMCID: PMC9069344, DOI: 10.1001/jama.2022.4798.Peer-Reviewed Original ResearchConceptsEarly tracheostomy groupEarly tracheostomyMechanical ventilationSevere strokeFunctional outcomeStandard tracheostomyTracheostomy groupPrimary outcomeControl groupProlonged invasive mechanical ventilationModified Rankin Scale scoreSevere disabilityInvasive mechanical ventilationSerious adverse eventsRankin Scale scoreAirway protective reflexesRate of survivalInvasive ventilationAdverse eventsHemorrhagic strokeWide confidence intervalsAvailable followProtective reflexesCare centerClinical trials
2021
Distinct roles of KLF4 in mesenchymal cell subtypes during lung fibrogenesis
Chandran RR, Xie Y, Gallardo-Vara E, Adams T, Garcia-Milian R, Kabir I, Sheikh AQ, Kaminski N, Martin KA, Herzog EL, Greif DM. Distinct roles of KLF4 in mesenchymal cell subtypes during lung fibrogenesis. Nature Communications 2021, 12: 7179. PMID: 34893592, PMCID: PMC8664937, DOI: 10.1038/s41467-021-27499-8.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell ProliferationDisease Models, AnimalDown-RegulationExtracellular MatrixFemaleFibroblastsFibrosisHumansKruppel-Like Factor 4LungLung InjuryMaleMesenchymal Stem CellsMiceMice, Inbred C57BLMyofibroblastsReceptor, Platelet-Derived Growth Factor betaRespiratory Tract DiseasesSignal TransductionTransforming Growth Factor betaConceptsMesenchymal cell typesPlatelet-derived growth factor receptorSmooth muscle actinLung fibrosisKruppel-like factor 4Forkhead box M1Growth factor receptorCell transitionCell typesExtracellular matrixDistinct rolesKLF4Box M1C chemokine ligandMesenchymal cell subtypesFactor receptorPro-fibrotic effectsFactor 4PDGFRMesenchymeCellsMacrophage accumulationKLF4 levelsChemokine ligandLung fibrogenesisGenes, environment, and developmental timing: New insights from translational approaches to understand early origins of respiratory diseases
Gutierrez MJ, Perez GF, Gomez JL, Rodriguez‐Martinez C, Castro‐Rodriguez J, Nino G. Genes, environment, and developmental timing: New insights from translational approaches to understand early origins of respiratory diseases. Pediatric Pulmonology 2021, 56: 3157-3165. PMID: 34388306, PMCID: PMC8858026, DOI: 10.1002/ppul.25598.Peer-Reviewed Original ResearchMeSH KeywordsDNA MethylationEpigenesis, GeneticEpigenomicsHumansMicroRNAsRespiratory SystemRespiratory Tract DiseasesConceptsDevelopmental timingHistone modificationsPotential molecular mechanismsEpigenetic paradigmEpigenetic reprogrammingGenetic reprogrammingDevelopmental programDNA methylationMolecular mechanismsMolecular programmingReprogrammingEarly originsGenesLatest insightsNew insightsOmicsMethylationMicroRNAsHomeostasisLife-long consequencesInsightsTranslational approachRespiratory mucosaRespiratory diseaseCurrent evidenceRelationship between flood severity and risk of hospitalisation in the Mekong River Delta of Vietnam
Phung DT, Warren JL, Chu CM, Dubrow R. Relationship between flood severity and risk of hospitalisation in the Mekong River Delta of Vietnam. Occupational And Environmental Medicine 2021, 78: 676-678. PMID: 34282039, DOI: 10.1136/oemed-2021-107768.Peer-Reviewed Original ResearchMeSH KeywordsClimate ChangeFloodsHospitalizationHumansInfectionsRespiratory Tract DiseasesRisk FactorsRiversSeasonsVietnamClearing the Haze: What Do We Still Need to Learn about Electronic Nicotine Delivery Systems?
Fucito LM, Malinosky H, Baldassarri SR, Herbst RS. Clearing the Haze: What Do We Still Need to Learn about Electronic Nicotine Delivery Systems? Cancer Prevention Research 2021, 14: 5-10. PMID: 33148678, PMCID: PMC8324047, DOI: 10.1158/1940-6207.capr-20-0394.Peer-Reviewed Original Research
2020
Increased incarceration rates drive growing tuberculosis burden in prisons and jeopardize overall tuberculosis control in Paraguay
Sequera V, Aguirre S, Estigarribia G, Cellamare M, Croda J, Andrews J, Martinez L, García-Basteiro A. Increased incarceration rates drive growing tuberculosis burden in prisons and jeopardize overall tuberculosis control in Paraguay. Scientific Reports 2020, 10: 21247. PMID: 33277515, PMCID: PMC7718226, DOI: 10.1038/s41598-020-77504-1.Peer-Reviewed Original ResearchMeSH KeywordsCommunicable DiseasesFemaleHumansMaleParaguayPrisonersPrisonsRespiratory Tract DiseasesTuberculosisConceptsTB casesPopulation attributable fractionAttributable fractionAnnual TB notification ratesNational TB Control ProgrammeOverall population attributable riskIncarcerated populationsTB control programsCharacteristics of tuberculosisPopulation attributable riskTB notification ratesTB control measuresTrend of tuberculosisPercentage of casesSame age groupIncarcerated casesTB burdenTB controlTuberculosis burdenCase RegistryTuberculosis controlTB epidemicAttributable riskNotification ratesRelative riskImaging in the Evaluation of Chest Pain in the Primary Care Setting, Part 2: Sources of Noncardiac Chest Pain
Bader AS, Rubinowitz AN, Gange CP, Bader EM, Cortopassi IO. Imaging in the Evaluation of Chest Pain in the Primary Care Setting, Part 2: Sources of Noncardiac Chest Pain. The American Journal Of Medicine 2020, 133: 1135-1142. PMID: 32442508, DOI: 10.1016/j.amjmed.2020.04.013.Peer-Reviewed Educational MaterialsMeSH KeywordsChest PainEsophageal Motility DisordersFractures, CompressionGastroesophageal RefluxHernia, HiatalHumansMagnetic Resonance ImagingMusculoskeletal DiseasesPleural EffusionPneumoniaPneumothoraxPrimary Health CareRadiography, ThoracicRespiratory Tract DiseasesRib FracturesSpinal FracturesThoracic WallTietze's SyndromeTomography, X-Ray ComputedConceptsChest painPrimary care settingCare settingsNoncardiac chest painCommon presenting complaintPrimary care physiciansMultiple organ systemsNoncardiac sourcesPresenting complaintCare physiciansMusculoskeletal etiologyRadiologic appearancePainNumerous imaging modalitiesOrgan systemsImaging modalitiesAppropriate testsEtiologyCliniciansFindingsPhysiciansSettingComplaintsThe Role of Chest Imaging in Patient Management During the COVID-19 Pandemic A Multinational Consensus Statement From the Fleischner Society
Rubin G, Ryerson C, Haramati L, Sverzellati N, Kanne J, Raoof S, Schluger N, Volpi A, Yim J, Martin I, Anderson D, Kong C, Altes T, Bush A, Desai S, Goldin J, Goo J, Humbert M, Inoue Y, Kauczor H, Luo F, Mazzone P, Prokop M, Remy-Jardin M, Richeldi L, Schaefer-Prokop C, Tomiyama N, Wells A, Leung A. The Role of Chest Imaging in Patient Management During the COVID-19 Pandemic A Multinational Consensus Statement From the Fleischner Society. CHEST Journal 2020, 158: 106-116. PMID: 32275978, PMCID: PMC7138384, DOI: 10.1016/j.chest.2020.04.003.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsRisk factorsChest radiographyCOVID-19Upper respiratory viral infectionRespiratory viral infectionsCoronavirus disease 2019 (COVID-19) pandemicUnprecedented health care crisisHealth care workersDisease 2019 pandemicPersonal protective equipmentHealth care deliveryPulmonary disease diagnosisHospitalized patientsRespiratory dysfunctionDisease progressionMild casesMultidisciplinary panelPretest probabilityChest imagingConsensus statementPatient managementRespiratory diseaseSevere casesCommunity transmissionViral infectionHarnessing Murine Microbiome Models to Study Human Lung Microbiome
Chang D, Sharma L, Dela Cruz CS. Harnessing Murine Microbiome Models to Study Human Lung Microbiome. CHEST Journal 2020, 157: 776-778. PMID: 32252931, PMCID: PMC7926993, DOI: 10.1016/j.chest.2019.12.011.Commentaries, Editorials and Letters
2019
Respiratory Health after Military Service in Southwest Asia and Afghanistan. An Official American Thoracic Society Workshop Report
Garshick E, Abraham JH, Baird CP, Ciminera P, Downey GP, Falvo MJ, Hart JE, Jackson DA, Jerrett M, Kuschner W, Helmer DA, Jones KD, Krefft SD, Mallon T, Miller RF, Morris MJ, Proctor SP, Redlich CA, Rose CS, Rull RP, Saers J, Schneiderman AI, Smith NL, Yiallouros P, Blanc PD. Respiratory Health after Military Service in Southwest Asia and Afghanistan. An Official American Thoracic Society Workshop Report. Annals Of The American Thoracic Society 2019, 16: e1-e16. PMID: 31368802, PMCID: PMC6774741, DOI: 10.1513/annalsats.201904-344ws.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsConstrictive bronchiolitisAirway diseaseRespiratory healthOfficial American Thoracic Society Workshop ReportRespiratory tract findingsRespiratory tract abnormalitiesAdverse health conditionsParticulate matter effectsU.S. military personnelLung biopsyLung functionPulmonary functionCase seriesPathologic findingsTract abnormalitiesInhalational exposurePhysiologic changesClinical characterizationAmerican Thoracic Society International ConferenceEpidemiologic studiesBronchiolitisLongitudinal assessmentDeployment exposuresHealth conditionsMore frequent encounters
2018
Opportunities on the road to value‐based payment for children with chronic respiratory disease
Kevill KA, Bazzy‐Asaad A, Pati S. Opportunities on the road to value‐based payment for children with chronic respiratory disease. Pediatric Pulmonology 2018, 54: 105-116. PMID: 30561848, DOI: 10.1002/ppul.24175.Peer-Reviewed Original ResearchChildChronic DiseaseFee-for-Service PlansHumansRespiratory Tract DiseasesValue-Based Health InsuranceEpidemiology of patients presenting to a pediatric emergency department in Karachi, Pakistan
Ijaz N, Strehlow M, Ewen Wang N, Pirrotta E, Tariq A, Mahmood N, Mahadevan S. Epidemiology of patients presenting to a pediatric emergency department in Karachi, Pakistan. BMC Emergency Medicine 2018, 18: 22. PMID: 30075749, PMCID: PMC6091113, DOI: 10.1186/s12873-018-0175-4.Peer-Reviewed Original ResearchConceptsPediatric emergency departmentEmergency departmentOutcomes of patientsAdvanced airway managementEpidemiology of patientsParticipants followed-upCare quality assessmentFollowed-upResource-poor countriesFollow-upAirway managementIV fluidsOtolaryngologic problemsED dispositionPediatric emergenciesPatientsPediatric EDPost-follow-upObservational studyOutpatient departmentBlood glucoseOutcome dataHigher mortalityMedical adviceConsecutive weeksFuture ozone-related acute excess mortality under climate and population change scenarios in China: A modeling study
Chen K, Fiore AM, Chen R, Jiang L, Jones B, Schneider A, Peters A, Bi J, Kan H, Kinney PL. Future ozone-related acute excess mortality under climate and population change scenarios in China: A modeling study. PLOS Medicine 2018, 15: e1002598. PMID: 29969446, PMCID: PMC6029756, DOI: 10.1371/journal.pmed.1002598.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge DistributionAge FactorsAgedAir PollutantsCardiovascular DiseasesCause of DeathChildChild, PreschoolChinaClimate ChangeEnvironmental MonitoringFemaleHealth StatusHumansInfantInfant, NewbornInhalation ExposureMaleMiddle AgedModels, TheoreticalOzonePopulation DynamicsPrognosisRespiratory Tract DiseasesRisk AssessmentRisk FactorsSeasonsTime FactorsUrban HealthVehicle EmissionsYoung AdultConceptsGlobal chemistry-climate modelChemistry-climate modelOzone-related mortalityRepresentative Concentration PathwaysEmission scenariosHigh global warmingGlobal warmingClimate changeChange scenariosOzone pollutionClimate Change (IPCC) Representative Concentration PathwaysEmission scenario RCP8.5Emission scenarios RCP4.5Future ozone projectionsStatistical downscaling approachModerate global warmingOzone precursor emissionsFine spatial resolutionSpatial resolutionHigh ambient ozoneOzone projectionsOzone changesOzone observationsScenario RCP8.5Change projections
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